
Researchers are seeking to determine whether adding the PARP inhibitor veliparib to a chemotherapy combination will improve outcomes for patients with HER2-negative, germline BRCA-associated metastatic or locally advanced breast cancer.
The international Brocade 3 trial, which is currently enrolling participants at more than 200 locations, seeks to randomize an estimated 500 patients in a 2:1 ratio to either veliparib with carboplatin and paclitaxel or a placebo plus the 2 chemotherapy agents.
The phase III study is open to patients whose tumors are triple negative as well as those with estrogen receptor (ER)- or progesterone receptor (PR)-positive disease because the biomarker of interest is not the hormone receptor, it is the BRCA mutation itself, according to principal investigator Shannon L. Puhalla, MD.
Link para a notícia: OncLive







