
Researchers at Okayama University describe in Scientific Reports that cancer-associated fibroblasts — cells that play a key role in cancer progression — originate from cancer stem cells.
Preventing cancer stem cells from transforming into cancer-associated fibroblast may be a promising approach towards cancer treatment.
Cancer progression is partly governed by a specialised type of cells known as cancer-associated fibroblasts (CAFs), as they have the ability to support/mediate different signalling pathways in a tumour microenvironment.
However, it is still unclear that how CAFs are generated.
Now, a team of researchers led by Masaharu Seno from Okayama University has provided the first evidence that CAFs may originate from cancer stem cells (CSCs) — the cells that can develop into any type of cell occurring in a given tumour.
Source: eCancer News







