Gut-associated lymphoid tissue represents an integral part of the immune system. Among the powerful players of the mucosa-associated lymphoid tissue are isolated lymphoid structures (ILSs). Additionally, researchers have shown that in the course of cancer, ectopic lymphoid structures (ELSs; also known as tertiary lymphoid structures, TLSs) are formed at the tumor site. Both ILSs and ELSs act as multitasking information centers triggering multifaceted immune responses.
An in-depth understanding of the complexity and functionality of ILSs and ELSs may lead to new directions in therapeutic interventions and/or provide help in treatment decisions as part of personalized medicine. A study recently published by researchers from MedUni Vienna and collaborative partners proposes ILSs as novel prognostic players orchestrating the pathobiology of metastatic colorectal cancer.
Cumulative data within the rapidly evolving field of immuno-oncology positions tumor infiltrating B cells among powerful contributors to anti-tumor immunity. One essential aspect that links the B-cell biology, adaptive immunity and the inflammation process to the tumor microenvironment is based on the unique ability of B cells to form ELSs. Central to this are germinal center reactions, which involve the coordinated action of various immune cell types with a central role given to B cells.
Source: Medical Xpress