
HER3 messenger RNA expression may serve as a biomarker for patients with RAS wild type colorectal cancer who will benefit from treatment with the anti-EGFR therapy panitumumab, according to the results of a study published in JAMA Oncology.
“We found no evidence for HER3 as a prognostic marker but found HER3 overexpression to be significantly associated with benefit from panitumumab,” wrote Jenny F. Seligmann, PhD, of Leeds Institute of Cancer and Pathology in the United Kingdom, and colleagues.
According to the study, previous research has shown that high EGFR ligand expression was predictive of panitumumab benefit in advanced colorectal cancer. Here, the researchers looked at the role of HER3 tumor RNA expression in samples of advanced colorectal cancer to try to determine if HER3 expression could further refine the RAS wild type population that will benefit from anti-EGFR agents.
Source: Cancer Network







