A greater depth of response (DepOR) to therapy was associated with prolonged overall survival (OS) and progression-free survival (PFS) for patients with non-small cell lung cancer (NSCLC) and may have clinical utility as an outcome measure of treatment efficacy, according to a study published in the Annals of Oncology.
With therapies such as ALK inhibitors (ALKi) and programmed cell death-1 (PD-1) inhibitors advancing rapidly, established methods of treatment efficacy may no longer be sufficient. DepOR, which measures the percent of maximal tumor reduction from baseline, may provide faster insights to the clinical efficacy of study treatments compared with the standard time-to-event outcome measurements such as PFS and OS.
For this retrospective analysis, the authors studied the results of 2 randomized controlled trials for ALKi and 2 for anti-PD-1.
Source: Oncology Nurse Advisor