
The combination of Abraxane (nab-paclitaxel) and carboplatin reduced the risk of progression or death by 40 percent compared with two other chemotherapy combinations as a frontline therapy for patients with metastatic triple-negative breast cancer (TNBC), according to recent findings from the phase 2 tnAcity study presented at the 2016 San Antonio Breast Cancer Symposium.
The median progression-free survival (PFS) was 7.4 months with Abraxane plus carboplatin compared with 5.4 months for Abraxane plus gemcitabine and six months for gemcitabine plus carboplatin. The 12-month PFS rate was 27 percent with Abraxane/carboplatin compared with 13 percent and 11 percent for Abraxane/gemcitabine and gemcitabine/carboplatin, respectively.
“I think it’s an exciting study because there’s such a role for doublet therapy, particularly in the triple-negative population. There’s a lot of controversy between sequential single-agent or doublet therapy,” said lead investigator Denise A. Yardley, M.D., senior investigator at the Sarah Cannon Research Institute. “The Abraxane/carboplatin arm in this phase 2 study came out demonstrating the ideal efficacy pattern for the triple-negative population.”
Link para a notícia: Cure Today







